Significance and Approach of Increasing Drug Loading in Solid Preparation of Traditional Chinese Medicine
10.13748/j.cnki.issn1007-7693.20224135
- VernacularTitle:提高中药固体制剂载药量的意义与途径
- Author:
Yuxuan DONG
1
;
Yan WANG
1
;
Yanlong HONG
2
;
Xiao LIN
3
;
Jiechen XIAN
1
;
Lijie ZHAO
1
;
Fei WU
1
;
Youjie WANG
1
Author Information
1. Shanghai University of Traditional Chinese Medicine Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education
2. Shanghai University of Traditional Chinese Medicine Shanghai Innovation Center of Traditional Chinese Medicine Health Service
3. Shanghai University of Traditional Chinese Medicine College of Chinese Materia Medica, Shanghai 201203, China
- Publication Type:Journal Article
- Keywords:
drug loading;
drug carrier;
traditional Chinese medicine preparations;
compliance of patients;
unification of medicines and excipients
- From:
Chinese Journal of Modern Applied Pharmacy
2024;41(3):420-427
- CountryChina
- Language:Chinese
-
Abstract:
Drug loading is an important index to evaluate the quality of solid preparation of traditional Chinese medicine. Drug loading is restricted by drug characteristics, dosage form, process, and drug delivery in vivo, which affects the preparation process, therapeutic effect, and drug release rate. By consulting domestic and foreign literature, this paper put forward the significance of increasing the drug loading: improving the compliance of patients, reducing the production cost, reducing the risk of the excipients. In this review, the possible approaches to increase drug loading, such as the selection of high-efficiency excipients, suitable drug preparation techniques, and modification of the physical properties of drugs are summarized. It will provide theoretical basis through this review for the development of high drug loading and high-quality formulations.
