Types of Major Microorganisms in Pharmaceutical Water Systems and Control Measures
10.13748/j.cnki.issn1007-7693.20221460
- VernacularTitle:制药用水系统中主要微生物类型及控制措施
- Author:
Yinghong LI
1
;
Linshuang ZHANG
1
;
Jue LI
1
;
Xiaoling ZHENG
1
;
Zhengnan WANG
1
;
Yinhuan WANG
1
;
Junhao CHEN
1
;
Liang HONG
2
;
Qiaofeng TAO
1
;
Huan CHEN
3
Author Information
1. Zhejiang Institute for Food and Drug Control, NMPA Key Laboratory for Testing and Warning of Pharmaceutical Microbiology, Key Laboratory of Drug Contacting Materials Quality Control of Zhejiang Province, Hangzhou 310052, China
2. Taizhou Institute for Drug Control, Taizhou 318000, China
3. Hangzhou Digital-Micro Biothch Co., Ltd., Hangzhou 311231, China
- Publication Type:Journal Article
- Keywords:
pharmaceutical water;
microbiology;
Burkholderia cepacia complex;
Ralstonia pickettii;
control measures
- From:
Chinese Journal of Modern Applied Pharmacy
2024;41(3):415-419
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE :To analyze the types and control measures of major microorganisms in pharmaceutical water systems, so as to provide guidance for effective control of pharmaceutical water systems.
METHODS
The main microbial species, abundance and harmfulness of drinking water, purified water and water for injection were reviewed, and the control measures on microorganisms in pharmaceutical water were discussed.
RESULTS
There were differences in the main microbial types in pharmaceutical water. Burkholderia cepacia complex and Ralstonia pickettii were conditioned pathogens in pharmaceutical water, thus causing certain biological safety hazards.
CONCLUSION
Pharmaceutical companies can strengthen the control of microorganisms in the water system by establishing microbial databases and common microbial strain banks at all levels. Trend analysis should to be conducted based on alert limits and action limits, so as to strengthen the control of microorganisms in the water system.
