Discussion on the Optimal Dose of Aspirin in the Treatment of Acute Stage of Kawasaki’s Disease
10.13748/j.cnki.issn1007-7693.20232054
- VernacularTitle:阿司匹林在川崎病急性期治疗中最佳剂量的探讨
- Author:
Jie MI
1
,
2
,
3
;
Zhuo LIU
1
,
2
,
3
;
Yuan LI
1
,
2
,
3
;
Yang LI
1
,
2
,
3
;
Ziyun DUAN
1
,
2
,
3
;
Wenwen ZHANG
1
,
2
,
3
;
Jiahua LIU
1
,
2
,
4
,
5
Author Information
1. Xi&rsquo
2. an Children&rsquo
3. s Hospital Department of Pharmacy
4. s Hospital Department of Clinical Laboratory, Xi&rsquo
5. an 710003, China
- Publication Type:Journal Article
- Keywords:
Kawasaki’s disease;
aspirin;
non-response to intravenous human immunoglobulin;
different doses
- From:
Chinese Journal of Modern Applied Pharmacy
2024;41(3):386-390
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE :To study the effect of different doses of aspirin on clinical efficacy in acute stage of Kawasaki’s disease, and to explore the optimal dose of aspirin.
METHODS
A total of 150 patients suffered from Kawasaki’s disease were randomly selected by hospital information system from March to May 2022 for retrospective analysis. According to different doses of aspirin, they were divided into three groups: high dose group(>50 mg·kg−1·d−1), medium dose group(30−50 mg·kg−1·d−1) and low dose group(<30 mg·kg−1·d−1). The antipyretic time, the incidence of non-response to intravenous human immunoglobulin, the improvement of laboratory indexes and prevalence of adverse drug reaction were compared among the three groups.
RESULTS
There was no significant difference in body temperature recovery among the three groups under different doses of aspirin. There was no significant difference in patients with non-response to intravenous human immunoglobulin among the three groups. Before treatment, there were no significant differences in white blood cell(WBC) count, blood platelet(PLT) count and C-reactive protein(CRP) concentration among the three groups. After treatment, the count of WBC, PLT and CRP in the three groups was significantly improved compared with that before treatment, and the difference was statistically significant(P<0.05). However, there was no significant difference in the above indexes among the three groups after treatment. There was a higher incidence of adverse reactions in children treated with medium or high dose aspirin.
CONCLUSION
Different doses of aspirin combined with intravenous human immunoglobulin have good therapeutic effect on Kawasaki’s disease, but considering the safety and economy of aspirin, low dose administration is recommended.
