Association between sleep and frailty: a Mendelian randomization study
10.19485/j.cnki.issn2096-5087.2024.12.017
- Author:
YANG Yudan
;
YANG Hong
;
LUO Peiyang
;
SONG Jie
;
SUN Xiaohui
;
YE Ding
;
MAO Yingying
;
LI Jiayu
- Publication Type:Journal Article
- Keywords:
sleep duration;
insomnia;
morning chronotype;
frailty;
Mendelian randomization
- From:
Journal of Preventive Medicine
2024;36(12):1082-1085,1091
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the association between sleep and frailty using the bidirectional two-sample Mendelian randomization (MR) approach, so as to provide the basis for the prevention and intervention of frailty.
Methods:The data on single nucleotide polymorphisms (SNP) related to sleep duration, insomnia and morning chronotype were collected from genome-wide association studies (GWAS) and meta-analysis of GWAS, involving 446 118, 1 331 010 and 697 828 participants, respectively. The frailty was evaluated using the frailty index, and the relevant SNP data were collected from a meta-analysis of GWAS involving 175 226 participants. A bidirectional MR analysis was performed using the inverse-variance weighted method. Sensitivity analyses employed the weighted median method, the maximum likelihood-based method, the MR-Egger regression, and the MR-PRESSO test.
Results:Forward MR analysis showed that longer sleep duration (β=-0.170, 95%CI: -0.255 to -0.085) and morning chronotype (β=-0.036, 95%CI: -0.058 to -0.014) decreased the risk of frailty, while insomnia increased the risk of frailty (β=0.167, 95%CI: 0.149-0.184). Reverse MR analysis showed that frailty increased the risk of insomnia (OR=1.645, 95%CI: 1.278-2.117). Both bidirectional MR results were robust, which excluded the impact of heterogeneity and horizontal pleiotropy.
Conclusion:Sleep duration, insomnia, and morning chronotype are associated with frailty.
- Full text:2024121615494712356睡眠与衰弱的孟德尔随机化研究.pdf
