Research Progress of Potential Regulatory Effects on Osteoporosis by BMP-mediated Smad Dependent and Smad Independent Pathways
10.13748/j.cnki.issn1007-7693.20231899
- VernacularTitle:骨形态发生蛋白介导的Smad依赖途径和Smad非依赖途径对骨质疏松症的潜在调节作用研究进展
- Author:
Yujie WANG
1
;
Fangyu AN
2
;
Chunlu YAN
3
;
Jiayi SONG
1
;
Weirong CHANG
1
;
Jie ZHANG
1
;
Zhipan XIAO
1
;
Peng GAO
1
;
Zhonghong LI
1
Author Information
1. Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
2. Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China;Key Laboratory of Molecular Medicine and Chinese Medicine Prevention and Treatment of Major Diseases in Gansu Universities, Lanzhou 730000, China
3. Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China;Key Laboratory of Molecular Medicine and Chinese Medicine Prevention and Treatment of Major Diseases in Gansu Universities, Lanzhou 730000, China;Gansu Provincial Research Center of Traditional Chinese Medicine, Lanzhou 730000, China
- Publication Type:Journal Article
- Keywords:
osteoporosis;
bone morphogenesis protein;
osteogenic differentiation;
adipogenic differentiation
- From:
Chinese Journal of Modern Applied Pharmacy
2024;41(2):277-286
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis can be induced by various factors including prolonged glucocorticoid usage, diminished estrogen levels, secondary hyperparathyroidism, and alterations in the microenvironment of bone tissue. The bone metabolism imbalance(osteogenic-lipogenic imbalance) plays a crucial role in the development of osteoporosis. This imbalance is primarily driven by an increase in the differentiation of bone marrow mesenchymal stem cells into adipocytes and a decrease in their differentiation into osteoblasts, thus forming the core of the osteogenic-lipogenic imbalance observed in osteoporosis. The bone morphogenesis protein(BMP) plays a crucial role in the regulation of the osteogenic-lipid balance in osteoporosis. This regulatory function is accomplished through both the Smad-dependent and Smad-independent pathways. This review centers on the Smad-dependent and Smad-independent pathways facilitated by BMP, offering a comprehensive overview of the potential mechanisms through which BMP-2, 4, 6, 7, and 9 contribute to the regulation of osteogenesis and lipid metabolism in osteoporosis via these pathways. In order to present novel insights for the identification of efficacious targets for clinical anti-osteoporosis medications.
