Research Progress of Potential Regulatory Effects on Osteoporosis by BMP-mediated Smad Dependent and Smad Independent Pathways
10.13748/j.cnki.issn1007-7693.20231899
- VernacularTitle:骨形态发生蛋白介导的Smad依赖途径和Smad非依赖途径对骨质疏松症的潜在调节作用研究进展
- Author:
Yujie WANG
1
;
Fangyu AN
1
,
2
;
Chunlu YAN
1
,
2
,
3
;
Jiayi SONG
1
;
Weirong CHANG
1
;
Jie ZHANG
1
;
Zhipan XIAO
1
;
Peng GAO
1
;
Zhonghong LI
1
Author Information
1. Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
2. Key Laboratory of Molecular Medicine and Chinese Medicine Prevention and Treatment of Major Diseases in Gansu Universities, Lanzhou 730000, China
3. Gansu Provincial Research Center of Traditional Chinese Medicine, Lanzhou 730000, China
- Publication Type:Journal Article
- Keywords:
osteoporosis;
bone morphogenesis protein;
osteogenic differentiation;
adipogenic differentiation
- From:
Chinese Journal of Modern Applied Pharmacy
2024;41(2):277-286
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis can be induced by various factors including prolonged glucocorticoid usage, diminished estrogen levels, secondary hyperparathyroidism, and alterations in the microenvironment of bone tissue. The bone metabolism imbalance(osteogenic-lipogenic imbalance) plays a crucial role in the development of osteoporosis. This imbalance is primarily driven by an increase in the differentiation of bone marrow mesenchymal stem cells into adipocytes and a decrease in their differentiation into osteoblasts, thus forming the core of the osteogenic-lipogenic imbalance observed in osteoporosis. The bone morphogenesis protein(BMP) plays a crucial role in the regulation of the osteogenic-lipid balance in osteoporosis. This regulatory function is accomplished through both the Smad-dependent and Smad-independent pathways. This review centers on the Smad-dependent and Smad-independent pathways facilitated by BMP, offering a comprehensive overview of the potential mechanisms through which BMP-2, 4, 6, 7, and 9 contribute to the regulation of osteogenesis and lipid metabolism in osteoporosis via these pathways. In order to present novel insights for the identification of efficacious targets for clinical anti-osteoporosis medications.
