Advances in immunomodulatory effects of catecholamines in critical illness.
10.3760/cma.j.issn.2095-4352.2019.10.023
- Author:
Chao LI
1
;
Jun LIU
;
Yunfu WU
Author Information
1. Department of Critical Care Medicine, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215001, Jiangsu, China. Corresponding author: Liu Jun, Email: liujunphd@sina.cn.
- Publication Type:Journal Article
- MeSH:
Catecholamines;
Critical Illness;
Humans;
Killer Cells, Natural;
Neutrophils
- From:
Chinese Critical Care Medicine
2019;31(10):1295-1298
- CountryChina
- Language:Chinese
-
Abstract:
Immune disorders are common in critically ill patients. Catecholamines play a crucial role in theimmune regulation and modulation. Immune cells can synthesize catecholamines and express adrenergic receptors. Catecholamine has a wide-ranging regulatory effect on innate immunity such as neutrophils, monocyte macrophages, dendritic cells, natural killer cells, and lymphocyte-mediated acquired immunity. Catecholamines exert different immunomodulatory effects by binding to α receptors, β receptors, and dopamine receptor subtypes on immune cells. In-depth study of the effect and mechanism of catecholamine on immune function in critically ill patients will provide new ideas for the prevention and treatment of immune dysfunction in critical illness.
