Progress of human CCAAT/enhancer binding protein epsilon on inflammation and infection.
10.3760/cma.j.issn.2095-4352.2019.10.022
- Author:
Yajun LIU
1
;
Tao CHEN
1
;
Huaping LIANG
2
Author Information
1. Department of Intensive Care Unit, the Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou, China.
2. Department of Wound Infection and Drug, Army Medical Center, Army Medical University (Third Military Medical University), Chongqing 400042, China. Corresponding author: Chen Tao, Email: 2395086838@qq.com.
- Publication Type:Journal Article
- MeSH:
Gene Expression Regulation;
Humans;
Infections;
Inflammation;
Neutrophils
- From:
Chinese Critical Care Medicine
2019;31(10):1292-1294
- CountryChina
- Language:Chinese
-
Abstract:
Inflammation and infection are main causes of death in critically ill patients. But traditional treatment are non-comprehensive and limited. Human CCAAT/enhancer binding protein epsilon (C/EBPε) is a key transcription factor regulating the terminal differentiation of neutrophils. It plays an important role in anti-inflammatory and anti-infective process by regulating inflammatory response cells. This article reviews the changes of C/EBPε in inflammation and infection, related regulatory mechanisms and targeted reversal measures, in order to provide references for exploring new directions and effective measures for inflammation and infection treatment.
