Research progress in glycogen metabolism reprogramming in sepsis associated immune cells.
10.3760/cma.j.issn.2095-4352.2019.09.023
- Author:
Danyang WANG
1
;
Meiyun LIU
2
;
Xin LYU
2
Author Information
1. Department of Anesthesiology, China-Japan Friendship Hospital of Jilin University, Changchun 130033, Jilin, China.
2. Department of Anesthesiology, Shanghai Pulmonary Hospital of Tongji University, Shanghai 200433, China. Corresponding author: Lyu Xin, Email: xinlv@126.com.
- Publication Type:Journal Article
- MeSH:
Dendritic Cells;
Glycogen;
Glycolysis;
Humans;
Oxidative Phosphorylation;
Sepsis
- From:
Chinese Critical Care Medicine
2019;31(9):1167-1169
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic reprogramming is the response of cells to environmental changes, such as cell activation, proliferation and differentiation, which involves changes in metabolism-related enzymes, metabolites and metabolic pathways. Sepsis-associated immune cells undergo metabolic reprogramming in response to inflammatory signals, which not only provides biological energy and biosynthesis requirements, but also determines cell fate and function in a highly specific way. In this paper, the changes in glycolysis, tricarboxylic acid cycle, oxidative phosphorylation and other glucose metabolism pathways of macrophages, T lymphocytes, dendritic cells, neutrophils and other sepsis related immune cells are described, so as to provide feasibility for future research and metabolic therapy.
