Progress of antimicrobial peptides cathelicidins in infection and immunology.
10.3760/cma.j.issn.2095-4352.2019.09.022
- Author:
Kuan LIU
1
;
Tao CHEN
1
;
Lixing TIAN
2
;
Jing WANG
2
;
Xin TANG
1
;
Huaping LIANG
1
Author Information
1. Department of Intensive Care Unit, the Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou, China.
2. State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Field Surgery, Daping Hospital, Army Medical University, Chongqing 400042, China. Corresponding author: Liang Huaping, Email: 13638356728@163.com.
- Publication Type:Journal Article
- MeSH:
Anti-Bacterial Agents;
Anti-Infective Agents;
Antimicrobial Cationic Peptides;
Bacteria;
Cathelicidins;
Humans
- From:
Chinese Critical Care Medicine
2019;31(9):1163-1166
- CountryChina
- Language:Chinese
-
Abstract:
Infection is one of the main causes of death in clinical patients, and multi-drug resistance leads to ineffective treatment with conventional antibiotics. Therefore, it is imperative to develop new anti-infective drugs. Antimicrobial peptides cathelicidins are cationic host defense peptides found in many organisms. It has been demonstrated by in vivo and in vitro studies that antimicrobial peptides cathelicidins not only show broad-spectrum antibacterial activity and high sensitivity to drug-resistant bacteria, but also have a good guiding effect on the immune response. This paper summarizes the reports of antimicrobial peptides cathelicidins in recent years, highlighting their research achievements in antibiosis, anti-inflammatory, chemotaxis regulation and phagocytosis, providing new ideas for the treatment of infection-related diseases.
