Comparison of SUVA/V and SUVA‑V for Evaluating AtheroscleroticInflammation in 18F‑FDG PET/CT
10.1007/s13139-023-00822-5
- Author:
Jeongryul RYU
1
;
Shin Ae HAN
;
Sangwon HAN
;
Sunju CHOI
;
Dae Hyuk MOON
;
Minyoung OH
Author Information
1. Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic‑Ro 43‑Gil, Songpa‑Gu, Seoul 05505, Republic of Korea
- Publication Type:ORIGINAL ARTICLE
- From:Nuclear Medicine and Molecular Imaging
2024;58(1):25-31
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:This study aimed to compare the clinical significance of two parameters, division of standardized uptake value (SUV) of target arterial activity by background venous blood pool activity ( SUVA/V ) and subtraction of background venous blood pool activity from SUV of target arterial activity (SUVA‑V ) of carotid arteries with atherosclerotic plaques using 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT).
Methods:Patients aged 50 years or more who were diagnosed with carotid artery stenosis of 50% or more with carotid Doppler ultrasonography and had torso 18F-FDG PET/CT were enrolled retrospectively and classified patients who developed cerebrovascular events (CVEs) within 5 years after 18F-FDG PET/CT scan as the active group and patients who did not experience the CVE within 5 years as an inactive group. We calculated SUVA/V and SUVA‑V using measurements of SUVmax
Results:SUVA‑V SUVA‑V_high , and SUVA‑V_low were significantly higher in the active group than in the inactive group, but neithe SUVA/V SUVA‑V_high , nor SUVA‑V_low showed significant differences between the active and inactive groups. Thedifference in rank between groups of SUVA‑V_high and SUVA‑V_low was greater than the difference in rank between groups of SUVA‑V_high and SUVA‑V_low . The CVE incidence differed between SUVA‑V_high and SUVA‑V_low of high carotid FDG uptake, but the CVE incidence did not differ between SUVA‑V_high and SUVA‑V_low of high carotid FDG uptake.
Conclusion:SUVA‑V may be a more rational solution than SUVA/V for evaluating atherosclerotic plaque inflammation on 18F-FDG PET/CT.
