The development status of PET radiotracers for evaluating neuroinflammation
10.1007/s13139-023-00831-4
- Author:
Namhun LEE
1
;
Jae Yong CHOI
;
Young Hoon RYU
Author Information
1. Division of Applied RI, Korea Institute of Radiological & Medical Sciences, 75 Nowon‑ro, Nowon‑gu, Seoul 01812, Korea
- Publication Type:REVIEW
- From:Nuclear Medicine and Molecular Imaging
2024;58(4):160-176
- CountryRepublic of Korea
- Language:English
-
Abstract:
Neuroinflammation is associated with the pathophysiologies of neurodegenerative and psychiatric disorders. Evaluating neuroinflammation using positron emission tomography (PET) plays an important role in the early diagnosis and determination of proper treatment of brain diseases. To quantify neuroinflammatory responses in vivo, many PET tracers have been developed using translocator proteins, imidazole-2 binding site, cyclooxygenase, monoamine oxidase-B, adenosine, cannabinoid, purinergic P2X7, and CSF-1 receptors as biomarkers. In this review, we introduce the latest developments in PET tracers that can image neuroinflammation, focusing on clinical trials, and further consider their current implications.
