Therapeutic Angiogenesis as a Potential Future Treatment Strategy for Erectile Dysfunction.
10.5534/wjmh.2012.30.2.93
- Author:
Ji Kan RYU
1
;
Jun Kyu SUH
Author Information
1. Department of Urology, National Research Center for Sexual Medicine, Inha University School of Medicine, Incheon, Korea. jksuh@inha.ac.kr
- Publication Type:Review
- Keywords:
Erectile dysfunction;
Endothelium;
Angiogenesis inducing agents
- MeSH:
Aluminum Hydroxide;
Angiogenesis Inducing Agents;
Carbonates;
Cardiovascular Diseases;
Caves;
Cyclic Nucleotide Phosphodiesterases, Type 5;
Endothelium;
Erectile Dysfunction;
Humans;
Male;
Muscle, Smooth;
Penile Erection;
Regeneration;
Stem Cells
- From:The World Journal of Men's Health
2012;30(2):93-98
- CountryRepublic of Korea
- Language:English
-
Abstract:
The cavernous endothelium plays a crucial role in regulating the tone of the underlying smooth muscle and physiologic penile erection. Recently, the link between erectile dysfunction (ED) and cardiovascular disease was unveiled, and the main etiology of ED was found to be vasculogenic. Although oral phosphodiesterase-5 inhibitors are generally effective for men with ED, such therapies do not cure underlying vasculopathy in the corpus cavernosum tissue. This review addresses current preclinical protein, gene, and cell or stem cell therapies for enhancing cavernous endothelial regeneration and restoring erectile function.
