Resective Epilepsy Surgery after Corpus Callosotomy in Children with Lennox-Gastaut Syndrome
- Author:
Soyoung PARK
1
;
Hye Eun KWON
;
Chung Mo KOO
;
Yun Jung HUR
;
Hoon-Chul KANG
;
Joon Soo LEE
;
Heung Dong KIM
Author Information
- Publication Type:Original article
- From: Annals of Child Neurology 2024;32(1):13-20
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:This study examined the characteristics and outcomes of resective epilepsy surgery following corpus callosotomy (CC) in children with Lennox-Gastaut syndrome (LGS).
Methods:We retrospectively analyzed 17 children with LGS who underwent resective surgery (RS) after CC over a span of 10 years, with a minimum of 2 years of follow-up, at a single tertiary epilepsy center in Korea.
Results:Of the 17 patients, 13 (73.5%) demonstrated favorable surgical outcomes (Engel class I or II) at 1 year after RS, and eight (47.1%) were ultimately free of seizures 2 years after surgery. A significantly larger decrease in the number of anti-seizure medications taken from before to 2 years after the final surgical procedure was observed in the group that became seizure-free than in the group with persistent seizures (P=0.062). Furthermore, a significantly greater decline in daily adaptive function was found in the persistent seizure group (P=0.059). The baseline characteristics, results of presurgical evaluation, and treatment-related factors assessed prior to surgery showed no significant differences between the seizure-free group and the group with persistent seizures.
Conclusion:In conclusion, RS may be a viable option for patients with LGS who exhibit lateralization and/or localization on presurgical evaluation after CC, as the procedure may reveal a concealed primary focus. The proactive implementation of two-stage epilepsy surgery could provide significant seizure reduction and preservation of cognitive function in carefully selected patients with LGS.
