Correlation Between SLCO1B3 Gene Polymorphism and Plasma Concentration of Tacrolimus in Renal Transplant Recipients
10.13748/j.cnki.issn1007-7693.20224301
- VernacularTitle:肾移植患者SLCO1B3基因多态性与他克莫司血药浓度相关性研究
- Author:
Hanshu ZHANG
1
;
Cangsang SONG
1
;
Xingde LI
1
;
Jinwei YANG
2
;
Panpan MAO
1
;
Guohui WANG
1
;
Xuejiao MA
1
Author Information
1. Department of Pharmacy, the First Hospital of Kunming, Kunming 650000, China
2. Affiliated Ganmei Hospital, Kunming Medical University, Kunming 650000, China
- Publication Type:Clinical Trial
- Keywords:
renal transplant;
tacrolimus;
blood concentration;
SLCO1B3;
polymorphisms
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(23):3297-3300
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the correlation between SLCO1B3 gene polymorphisms and early postoperative tacrolimus concentrations in renal transplant recipients. METHODS A total of 68 patients who underwent kidney transplantation in the First Hospital of Kunming were selected, tacrolimus plasma concentrations were monitored by chemoluminescence, CYP3A5*3, SLCO1B3 T334G and G699A gene polymorphisms were detected by polymerase chain reaction, and genotyping was performed to analyze the correlation between each genotype and tacrolimus plasma concentrations. RESULTS Different genotypes of CYP3A5*3 had significant effects on postoperative tacrolimus plasma concentration and standardized plasma concentration(P＜0.05), and different genotypes of SLCO1B3 T334G and G699A gene loci had no significant effect on postoperative tacrolimus plasma concentration and standardized plasma concentration. CONCLUSION Compared with CYP3A5*3/*3 genotype, CYP3A5*1 allele carriers need to reach the same tacrolimus concentration to increase tacrolimus dose. SLCO1B3 T334G and G699A gene polymorphisms has no effect on tacrolimus plasma concentration in the early stage after renal transplantation.
