Research Progress of Plant Exosome-like Nanovesicles
10.13748/j.cnki.issn1007-7693.20222683
- VernacularTitle:植物外泌体样纳米囊泡的研究进展
- Author:
Wenjing LI
1
;
Ruishi XIE
2
;
Song YANG
1
;
Limei REN
1
;
Yueming ZHAO
1
;
Jiawen WANG
1
Author Information
1. Changchun University of Traditional Chinese Medicine, Jilin Ginseng Science Academy, Changchun 130117, China
2. Changchun University of Traditional Chinese Medicine, College of Pharmacy, Changchun 130117, China
- Publication Type:Other Types
- Keywords:
plant exosome-like nanovesicles , extraction and separation , biological functions , therapeutic molecular delivery , new nano-therapy techniques
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(24):3459-3466
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:Plant exocrine-like nanovesicles(PELNs) is a new nano-therapeutic agent and delivery platform, which not only has the potential for disease treatment, but also can be used as a drug carrier to target disease sites and play a dual role in treatment and delivery. More importantly, PELNs has the characteristics of green nature and low immunogenicity. This review systematically introduced several secretory mechanisms of PELNs:Outer capsule positive organelle, polyvesicular body, vacuole and autophagosome; three components such as lipid, protein and nucleic acid; centrifugation, ultrafiltration, size exclusion chromatography, flow field-flow fractionation, immunomagnetic beads, polymer precipitation and other separation methods and their biological functions such as anti-inflammation, anti-tumor, protection of regeneration, antivirus, liver protection, etc.; sorted out the potential mechanism of PELNs as a therapeutic agent and molecular delivery platform, and put forward the problems existing in the research process of PELNs, such as quantification, mechanism research and few clinical trials. And its development potential in the future is discussed.
