Perioperative transfusion strategies for patients with rare coagulation factor deficiency:a case report of coagulation factor antecedent deficiency with hemangioma of knee joint and literature review
10.13303/j.cjbt.issn.1004-549x.2024.10.005
- VernacularTitle:罕见凝血因子缺乏症患者围术期输血策略
- Author:
Zhengxin SUO
1
,
2
;
Li WANG
;
Yingying NIU
;
Chunyan HUANG
Author Information
1. 四川大学华西医院输血科,四川成都 610041
2. 四川大学华西天府医院输血科,四川成都 610041
- Keywords:
rare coagulation factor deficiency;
blood transfusion;
perioperative
- From:
Chinese Journal of Blood Transfusion
2024;37(10):1122-1125
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the perioperative blood transfusion strategy of patients with hereditary coagulation fac-tor deficiency through the perioperative blood coagulation management of a patient with coagulation factor Ⅺ deficiency and hemangioma of knee joint.Methods Coagulation factor activity test and gene test were used to confirm the patients with co-agulation factor Ⅺ antecedent deficiency.Perioperative bleeding risk assessment,thromboela-stogram(TEG)and coagula-tion factors detection were performed to detect the coagulation status of the patients.400 mL fresh frozen plasma was trans-fused before surgery and first day after surgery,200 mL daily for 3 days thereafter.Results The level of APTT was con-trolled from 97.1 s before operation to 36.9 s after operation.There was no obvious bleeding during operation,and the wound healed well after operation.Conclusion In the situation of lack of commercial coagulation factors,transfusion of blood products such as fresh frozen plasma can significantly improve the coagulation function and reduce the risk of intraoperative bleeding in patients with hereditary coagulation factor deficiency during perioperative period.
