Autologous leukocyte-poor platelet-rich plasma injection in the treatment of knee osteoarthritis:short-term clinical effect analysis
10.13303/j.cjbt.issn.1004-549x.2024.10.004
- VernacularTitle:自体贫白细胞富血小板血浆注射治疗膝骨关节炎短期临床疗效观察及分析
- Author:
Lei YANG
1
;
Doudou JING
;
Mingxi LIU
;
Zhenye GUO
;
Binai YANG
;
Shuzhong LIN
;
Demei ZHANG
;
Fengyan GUO
;
Jin LIU
Author Information
1. 北京大学第一医院太原医院(太原市中心医院)输血科,山西太原 030013
- Keywords:
knee osteoarthritis(KOA);
LP-PRP;
VAS;
WOMAC;
clinical effect
- From:
Chinese Journal of Blood Transfusion
2024;37(10):1115-1121
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate short-term clinical efficacy of autologous leukocyte-poor platelet-rich plasma(LP-PRP)treatment of knee osteoarthritis(KO A).Methods 85 cases of patients with Keligren Lawrence grade Ⅰ-Ⅲ knee os-teoarthritis in Peking University First Hospital Taiyuan Hospital(Taiyuan Central Hospital)from 2022 to 2023 were collect-ed for autologous LP-PRP collection and quality assessment using a blood component separator,and all patients were treated with autologous LP-PRP.The degree and function of knee pain were assessed by visual analog scale(VAS)and knee arthri-tis index scale(WOMAC)at 1,3 and 6 months after injection.Knee MRI was performed after 6 months of treatment,and the MRI imaging changes before and after treatment were compared.Different influencing factors in the treatment results were grouped and analyzed,mainly including platelet concentration in LP-PRP and K-L grading of knee joint.According to the platelet concentration in LP-PRP,it was divided into three grades,which are low concentration[(＜800)×109/L],medium concentration[(800-1 000)×109/L],and high concentration[(＞1 000)× 109/L];According to the K-L grade of the knee joint,the severity of knee osteoarthritis was divided into three grades:Ⅰ、Ⅱ、Ⅲ.Results The VAS and WOMAC scores at 1,3 and 6 months after LP-PRP treatment were significantly lower than those before treatment,and the difference was sta-tistically significant(P＜0.05).There was a statistically significant difference in the therapeutic effect of different levels of platelet concentration,and when the platelet concentration was more than 1 000×109/L,the significant effect was the most obvious(P＜0.05).The therapeutic effect of different levels of platelet concentration was statistically significant(P＜0.05).MRI showed that the articular cartilage signal was significantly improved after treatment.Conclusion Autologous LP-PRP injection into knee cavity for the treatment of KO A has a good short-term clinical effect in relieving knee pain.
