Expression of secretory protein DKK1 in cervical cancer and its clinical significance
10.19405/j.cnki.issn1000-1492.2022.01.030
- Author:
Qingqing Yang
1
;
Chang Duan
1
;
Haofan Wang
1
;
Dongyuan Jiang
1
;
Qingfeng Tian
2
;
Quanling Feng
1
Author Information
1. Dept of Obstetrics and Gynecology, The Third Afiliated Hospital of Zhengzhou University, Zhengzhou 450000
2. School of Public Health , Zhengzhou University, Zhengzhou 450000
- Publication Type:Journal Article
- Keywords:
cervical cancer;
DKK1;
pathological features
- From:
Acta Universitatis Medicinalis Anhui
2022;57(1):157-160
- CountryChina
- Language:Chinese
-
Abstract:
Objective : To study the expression and clinical significance of Wnt signal secretory protein DKK1 in cervical cancer.
Methods :Reverse transcription polymerase chain reaction (RT⁃PCR) was used to detect the expression of DKK1 mRNA in 30 pairs of cervical cancer tissues and adjacent normal tissues. The expression of DKK1 protein was detected by immunohistochemistry in 60 cases of cervical cancer and 30 cases of normal cervical tissue , and the relationship between the expression and clinicopathological characteristics of cervical cancer was analyzed.
Results :The expression of DKK1 in cervical cancer tissues was lower than that in adjacent tissues and normal cervical tissues (P < 0. 05) . The expression of DKK1 was closely related to clinicopathological stage , tissue differentiation , lymph node metastasis and depth of invasion (P < 0. 05) .
Conclusion :The expression of DKK1 is low in cervical cancer and plays an important role in the occurrence and development of cervical cancer.
- Full text:2024120416570423537分泌型蛋白DKK1在宫颈癌中的表达及其临床意义_杨晴晴.pdf
