Mechanism of cuproptosis and its role in liver diseases
- VernacularTitle:铜死亡的发生机制及在肝脏疾病中的作用
- Author:
Mingqiang ZHU
1
;
Xing XIE
;
Qicheng LIAO
;
Xiao HE
;
Youming DING
;
Xiaohua WANG
Author Information
- Keywords: Copper; Cell Death; Liver Diseases
- From: Journal of Clinical Hepatology 2024;40(11):2332-2337
- CountryChina
- Language:Chinese
- Abstract: Cuproptosis is a new type of cell death that depends on intracellular copper accumulation to trigger the aggregation of mitochondrial lipoacylated protein and the degradation of iron-sulfur cluster protein,with a different mechanism of action from autophagy,ferroptosis,pyroptosis,and necroptosis.Cuproptosis is closely association with the development of liver cancer and resistance to antitumor drugs,as well as the progression of various liver diseases such as hereditary liver diseases,nonalcoholic fatty liver disease,viral hepatitis,and liver cirrhosis.This article summarizes the mechanism of cuproptosis and its role in liver diseases,in order to provide a reference for further research and treatment of liver diseases.
