Preventive and therapeutic effects of berberine on liver diseases and its mechanism

VernacularTitle:黄连素对肝脏疾病的防治作用及其机制
Author: Huili WANG ^{1
,

2} ; Wenhao QIN ; Dangdang YANG ; Yaqian NING ; Shan LIN ; Songlin DAI ; Bing HU
Author Information

1. 广东药科大学临床医学院,广州 510000
2. 海军军医大学第三附属医院消化内科,上海 200438
Keywords: Berberine; Liver Diseases; Therapeutics
From: Journal of Clinical Hepatology 2024;40(11):2326-2331
CountryChina
Language:Chinese
Abstract: Berberine is an antipyretic and detoxicating drug commonly used in clinical practice,and it is currently used for the routine treatment of gastrointestinal diseases such as bacterial gastroenteritis and diarrhea.However,several recent studies have shown that berberine can exert a therapeutic effect on the diseases such as autoimmune hepatitis,viral hepatitis,nonalcoholic fatty liver disease,and liver cancer by regulating the AMPK and TGF-β pathways and altering the composition of intestinal flora.This provides new drugs for the treatment of these diseases,expands the potential indications of berberine,and provides clues for the follow-up research and development of similar drugs.This article summarizes the therapeutic effect and mechanism of berberine on various liver diseases,in order to provide a reference for effective clinical application.