The role of tumor necrosis factor-α in the development and progression of hepatocellular carcinoma
- VernacularTitle:肿瘤坏死因子α在肝细胞癌发生发展中的作用
- Author:
Lingling ZHU
1
,
2
;
Yani ZHANG
;
Tingting SHI
;
Yang WU
;
Chun GAO
;
Xiaohui YU
;
Yujing HE
;
Jiucong ZHANG
Author Information
- Keywords: Carcinoma,Hepatocellular; Tumor Necrosis Factor-alpha; Signal Transduction; Molecular Targeted Therapy
- From: Journal of Clinical Hepatology 2024;40(11):2320-2325
- CountryChina
- Language:Chinese
- Abstract: Tumor necrosis factor-α(TNF-α)is involved in the regulation of multiple biological processes such as the proliferation,invasion,migration,and chemotherapy resistance of hepatocellular carcinoma(HCC)cells through TNF receptor-mediated signaling pathways.At the same time,TNF-α also plays a role in inducing the apoptosis of HCC cells.Some TNF-α inhibitors have been shown to inhibit the progression of HCC and prolong survival time.At present,the potential mechanism of action of TNF-α in HCC remains unclear,and exploration of the interaction between TNF-α and HCC can help to determine the potential therapeutic targets for HCC.This article summarizes the latest research advances in the mechanism of action of TNF-α in HCC and introduces the possibility of targeting TNF-α as a treatment method for HCC,in order to provide a theoretical basis for the prevention and treatment of liver cancer and drug research and development.
