The mechanism of autophagy inducing drug resistance of hepatocellular carcinoma
- VernacularTitle:自噬介导肝细胞癌耐药的相关机制
- Author:
Runbing ZHANG
1
,
2
;
Tingting SHI
;
Yang WU
;
Jiucong ZHANG
;
Xiaofeng ZHENG
Author Information
- Keywords: Carcinoma,Hepatocellular; Autophagy; Drug Resistance,Neoplasm
- From: Journal of Clinical Hepatology 2024;40(11):2315-2319
- CountryChina
- Language:Chinese
- Abstract: Treatment resistance of hepatocellular carcinoma(HCC)is an important factor restricting its treatment outcome.Autophagy is a process involving multiple steps and targets and is closely associated with the proliferation and apoptosis of tumor cells.At the same time,there is significant crosstalk between autophagy and tumor treatment resistance.Therefore,autophagy may be one of the key factors hindering tumor cell death after medical intervention.Transforming growth factor-β(TGF-β),epithelial-mesenchymal transition(EMT),and long non-coding RNA(lncRNA)are important factors leading to drug resistance of HCC.This article discusses the possible mechanism of TGF-β,EMT,and lncRNA mediating complex molecular networks and inducing drug resistance of HCC,in order to provide new ideas for improving the sensitivity of HCC treatment.
