The role of endoplasmic reticulum stress in non-alcoholic fatty liver disease and related targeted therapies
- VernacularTitle:内质网应激在非酒精性脂肪性肝病中的作用及相关靶向治疗
- Author:
Xiuyan LI
1
;
Na LEI
;
Hongfei SONG
;
Ling ZENG
;
Dong WANG
;
Jie MU
Author Information
- Keywords: Non-alcoholic Fatty Liver Disease; Endoplasmic Reticulum Stress; Unfolded Protein Response; Molecular Targeted Therapy
- From: Journal of Clinical Hepatology 2024;40(11):2300-2305
- CountryChina
- Language:Chinese
- Abstract: Non-alcoholic fatty liver disease(NAFLD)is a series of diseases characterized by hepatic steatosis and is also a metabolism-associated disease and an important factor for liver fibrosis,liver cirrhosis,and hepatocellular carcinoma.Endoplasmic reticulum is a core organelle for the regulation of lipid metabolism,and unfolded protein response is an important process of endoplasmic reticulum stress(ERS).Based on the important stress role of endoplasmic reticulum in metabolism-associated diseases,this article explores the influencing mechanism between ERS and NAFLD and reviews the research advances in lipid metabolism,inflammatory response,hepatocyte death,fibrosis,and ERS-targeted therapies in the pathological development of NAFLD.
