Research advances of noninvasive diagnosis of fibrotic non-alcoholic steatohepatitis

VernacularTitle:纤维化非酒精性脂肪性肝炎无创诊断的研究进展
Author: Gong FENG ^{1
,

2} ; Rongyao KONG ; Jiaxue WANG ; Tianyue WU ; Xiaohui WU ; Juning WANG ; Qinqin YAN ; Man MI
Author Information

1. 西安医学院全科医学研究所,西安 710021
2. 西安交通大学第一附属医院感染科,西安 710061
Keywords: Non-alcoholic Fatty Liver Disease; Fibrosis; Biomarkers; Diagnosis; Artificial Intelligence
From: Journal of Clinical Hepatology 2024;40(11):2293-2299
CountryChina
Language:Chinese
Abstract: A subset of patients with non-alcoholic fatty liver disease(NAFLD)can progress to nonalcoholic steatohepatitis(NASH).When NASH reaches a fibrosis degree of F≥2 and a NAS score of≥4,this stage of NASH is referred to as fibrotic NASH,which is a key focus in clinical drug trials.Currently,liver biopsy is the gold standard for assessing the histological changes of the liver,but its clinical application is limited by its invasiveness,and therefore,it is of particular importance to develop noninvasive detection methods for fibrotic NASH.This article summarizes the recent research achievements in novel noninvasive diagnostic methods for fibrotic NASH and elaborates on these new diagnostic methods for predicting fibrotic NASH in terms of current status,challenges faced,and prospects for future development.