Correlation analysis of α1⁃antitrypsin , CXCL12 , IL⁃15Rα and prognosis of patients with HIV infection
10.19405/j.cnki.issn1000-1492.2022.01.029
- Author:
Ling Liu
1
;
Hongshuai Xu
2
;
Junling Zhao
3
Author Information
1. Laboratory Teaching Center of Basic Medicine , Jinzhou Medical University, Jinzhou 121000
2. Dept ofInfectious Disease , Jinzhou Infectious Dsease Hospital , Jinzhou 121017
3. Dept of E. N. T. , The First Afiliated Hospital of Jinzhou Medical University, Jinzhou 121000
- Publication Type:Journal Article
- Keywords:
AIDS;
viral infection;
α1 ⁃antitrypsin;
chemokines
- From:
Acta Universitatis Medicinalis Anhui
2022;57(1):153-156
- CountryChina
- Language:Chinese
-
Abstract:
Objective : To explore the correlation between α 1 ⁃antitrypsin , CXCL12 , IL⁃15Ralpha and the prognosis of HIV⁃infected patients.
Methods :A total of 154 HIV⁃infected patients were selected , and 154 healthy volun⁃ teers were randomly selected from our hospital for physical examination and divided into control group. According to the stage of the disease , the patients were divided into stage I , stage II , stage Ⅲ and stage Ⅳ. Western blot was
used to detect the expression of α 1 ⁃antitrypsin and CXCL12 , PC⁃PCR was used to detect the expression of IL⁃15Rα , and indirect method was used to detect the levels of CD3 and CD4.
Results :Compared with the control group , the levels of CD4 and CD8 in AIDS group decreased abnormally , and the difference was statistically significant (P < 0. 05) ; compared with the control group , the expression of α 1 ⁃antitrypsin , CXCL12 , IL⁃15Rα in AIDS group increased (P < 0. 05) ; compared with stage I patients , the expression of α 1 ⁃antitrypsin , CXCL12 , IL⁃15Rα in patients with stage Ⅱ increased (P < 0. 05) ; compared with stage Ⅱ patients , the expression of α 1 ⁃antitrypsin , CXCL12 , IL⁃15Rα increased (P < 0. 05) ; compared with patients in stage Ⅲ , the expression of α 1 ⁃antitrypsin , CXCL12 and IL⁃15Rα in patients with stage Ⅲ was higher (P < 0. 05) ; compared with patients in stage III , the expressions of α 1 ⁃antitrypsin , CXCL12 and IL⁃15Rα in patients with stage IV increased (P < 0. 05) .
Conclusion:α 1 ⁃antitrypsin , CXCL12 and IL⁃15Rα are closely related to HIV infection and prognosis of HIV infected patients.
- Full text:2024120317203150439α1-抗胰蛋白酶、CXCL...毒感染患者预后的相关性分析_刘凌.pdf
