Diagnostic accuracy and safety of endoscopic – Guided office-based biopsies for laryngeal and pharyngeal lesions at St. Luke’s Medical Center
https://doi.org/10.32412/pjohns.v39i2.2171
- Author:
Diana R. Fernandez
1
;
Ronaldo G. Soriano
1
Author Information
1. Department of Otolaryngology - Head and Neck Surgery, St. Lukes Medical Center
- Publication Type:Journal Article
- Keywords:
flexible endoscopic biopsy;
office-based biopsy
- MeSH:
Head and Neck Neoplasms;
Malignancy;
Neoplasms
- From:
Philippine Journal of Otolaryngology Head and Neck Surgery
2024;39(2):12-16
- CountryPhilippines
- Language:English
-
Abstract:
Objective:To determine the sensitivity, specificity, positive predictive value, negative predictive value and safety of endoscopic guided office-based biopsies (OBB) in diagnosing laryngeal and pharyngeal neoplasms at the St. Luke’s Medical Center in Quezon City and Global City.
Methods
Design:Diagnostic Accuracy Study
Setting:Two Tertiary Private Training Hospitals
Participants:Records of patients with pharyngeal and laryngeal lesions who underwent endoscopic-guided OBB were included in the study describing safety. Only patients with subsequent operative biopsies were included in assessing diagnostic accuracy.
Results:Thirty-six (36) patients were included: 28 (77.78%) males and 8 (22.22%) females, with median age of 61.5 (IQR 52-73 years). Nearly half (16/36; 44.44%) of the office-based biopsies yielded malignant histopathology results, 19.44% had high grade dysplasia while 36.11% had benign findings. Of 10 patients with operative biopsy for definitive diagnosis, 8 were correctly diagnosed with carcinoma while one had a change in diagnosis from benign to malignant. Office based biopsy was well tolerated and had no complications reported. Overall, the sensitivity of OBB in predicting malignancy was 88.89%, specificity was 100%, positive predictive value was 100%, and negative predictive value was 50%.
Conclusion:Office-based biopsy is an accurate, reliable and safe modality for screening suspicious pharyngeal and laryngeal neoplasms, and may be part of routine screening during initial endoscopy among selected patients with suspicious pharyngeal and laryngeal neoplasms. Further investigation and larger population studies may provide more robust insights on effectiveness and safety of office-based biopsy in diagnosis of pharyngeal and laryngeal neoplasms.
- Full text:2024120309523343215D.pdf
