Meta-analysis of domestic rotavirus vaccine effectiveness for rotavirus gastroenteritis in children
10.13200/j.cnki.cjb.004329
- VernacularTitle:国产轮状病毒疫苗对儿童轮状病毒性胃肠炎保护效果的Meta分析
- Author:
CHEN Jun
- Publication Type:Journal Article
- Keywords:
Rotavirus vaccine;
Rotavirus gastroenteritis(RVGE);
Randomized controlled trials(RCTs);
Cohort study(CT);
Effectiveness;
Meta analysis
- From:
Chinese Journal of Biologicals
2024;37(11):1334-1340+1348
- CountryChina
- Language:Chinese
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Abstract:
Objective To evaluate the vaccine effectiveness(VE) of the domestic rotavirus(RV) vaccine, Lanzhou lamb rotavirus vaccine(LLRV), for rotavirus gastroenteritis(RVGE) and severe rotavirus gastroenteritis(SRVGE) in children by Metaanalysis, and to provide evidence-based medical evidence for guiding the application of domestic RV vaccine.Methods The literature on LLRV published in 2001-2022 were searched, and the randomized controlled trials(RCTs) or cohort studies(CT) about VE research on LLRV to RVGE and SRVGE, which met the inclusion criteria, were selected as the research objects. PubMed, Cochrane Library(CL), China National Knowledge Infrastructure(CNKI), VIP, Wanfang Database(WF) and conference paper database were searched, the collated reported data was analyzed through RevMan 5.3 software,and the heterogeneity test was performed. The random effect model(REM)(P ≤ 0.1) or fixed effect model(FEM)(P > 0.1)were used to combine the relative risk(RR) reported in the literature, and the combined RR and 95% CI were calculated.Results A total of 27 studies about VE research on LLRV to RVGE were included, all of which were Chinese literature. The VE of LLRV for RVGE was 65%(95% CI: 61%-69%) in children inoculated with LLRV, and the VE for SRVGE was 78%(95% CI: 65%-84%).Conclusion LLRV has a significant VE on RVGE and SRVGE, which can significantly reduce the incidence and severe gastroenteritis cases of RVGE and SRVGE in children in China.
