Research progress on the functions of BORIS and related drug development
10.16438/j.0513-4870.2024-0321
- VernacularTitle:BORIS的功能及相关药物研究进展
- Author:
Dong XU
;
Duo LU
- Publication Type:Research Article
- Keywords:
BORIS;
3D genome;
cancer-testis antigen;
molecular mechanism;
rug development strategy
- From:
Acta Pharmaceutica Sinica
2024;59(7):1905-1915
- CountryChina
- Language:Chinese
-
Abstract:
Brother of regulator of imprinted sites (BORIS), also known as CCCTC binding factor-like (CTCFL), is a relatively newly discovered cancer-testis antigen. Drug development related to BORIS has been carried out in multiple directions, including small molecules, small RNA molecules, polypeptides, vaccines, and cellular therapies. Due to its unique ability to interfere with the higher-order spatial structure of the genome, BORIS may represent a new class of drug targets. Here we systematically review the molecular biology research results related to BORIS, including the diversity of its gene products, the multipartite interactions mediated by BORIS, the subsequent impact on signaling pathways, and current drug development strategies, in order to gain a better understanding of the molecular mechanisms of BORIS in both upstream and downstream regulation networks and to identify potential research directions for further breakthroughs.
