Research progress on the regulation of ferroptosis by lipid droplet metabolism
10.16438/j.0513-4870.2024-0057
- VernacularTitle:脂滴代谢调控铁死亡的研究进展
- Author:
Quan-ao JIANG
1
;
Ran DENG
1
;
Shi-lin XIA
2
;
Xiao-man JIANG
2
;
Jing XU
2
;
Hong WU
2
Author Information
1. School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230012, China
2. Anhui Province Key Laboratory of Research and Development of Chinese Medicine, Key Lab of Xin′an Medicine, Ministry of Education, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
- Publication Type:Research Article
- Keywords:
lipid droplet;
ferroptosis;
polyunsaturated fatty acid;
monounsaturated fatty acid;
lipolysis;
lipid droplet biogenesis
- From:
Acta Pharmaceutica Sinica
2024;59(7):1897-1904
- CountryChina
- Language:Chinese
-
Abstract:
As a novel iron-dependent form of cell death, ferroptosis is characterized by the excessive accumulation of phospholipids containing polyunsaturated fatty acids (PUFA) on the cell membrane and peroxidation. Lipid droplets are always in the dynamic transition of generation and decomposition, play a central role in regulating lipid metabolism, and are always in the dynamic transition of generation and decomposition. Lipid droplet metabolism is closely related to the occurrence of ferroptosis and plays an important role in the disease caused by ferroptosis. This review firstly focuses on the lipid droplet metabolism process and its effects on the storage and release of PUFA, and further elucidates the regulatory mechanism and key regulatory proteins of lipid drop metabolism on ferroptosis, in order to reveal the intrinsic relationship between lipid droplets and ferroptosis, and provide a new strategy for disease prevention and treatment.
