Studies on the chemical composition of Ferula feruloides
10.16438/j.0513-4870.2023-1424
- VernacularTitle:多伞阿魏化学成分研究
- Author:
Ying-he BI
1
;
Ke-jian PANG
2
;
Hui-zi LI
1
;
Yerlan BAHETJAN
1
;
Muguli MUHAXI
2
;
Yan HU
1
;
Xin-zhou YANG
1
Author Information
1. College of Pharmacy, South-Central Minzu University, Wuhan 430074, China
2. Yili Normal University, Yining 835000, China
- Publication Type:Research Article
- Keywords:
italic>Ferula L.;
italic>Ferula feruloides;
chemical composition;
coumarin;
sesquiterpene
- From:
Acta Pharmaceutica Sinica
2024;59(7):2069-2076
- CountryChina
- Language:Chinese
-
Abstract:
Eleven compounds were isolated and purified from the ethyl acetate part of 80% ethanol extract of Ferula feruloides root by a combination of normal-phase silica gel column chromatography, Sephadex LH-20 dextran gel column chromatography and semi-preparative liquid chromatography and then modern wave spectrometry methods (NMR, MS, UV, IR) were used to identify the structures of the compounds, which were identified as baigene D (1), baigene E (2), baigene F (3), β-kirialovin (4), α-kirialovin (5), falcarindiol (6), ammoresinol (7), dshamirone (8), 2,3-dihydro-7-hydroxy-2S*,3R*-dimethyl-3-[4-methyl-5-(4-methy1-2-furyl)-3(E)-pentenyl]-furo[3,2-c]coumarin (9), 2,3-dihydro-7-hydroxy-2S*,3R*-dimethyl-2-[4,8-dimethyl-3(E),7-nonadi-enyl]-furo[3,2-c]coumarin (10), and baigene C (11). Compounds 1-3 are new coumarin analogues, and compounds 4-6 are firstly isolated from F. feruloides. The anti-proliferative activity of compounds 5, 7-11 against human gastric cancer (MKN-45) cells was evaluated using MTT assay, which showed that compounds 7-11 exhibited strong inhibitory activity, and compound 5 exhibited weak inhibitory activity.
