Research progress on the endocytosis pathway of nanoscale metal-organic frameworks drug carriers
10.16438/j.0513-4870.2024-0226
- VernacularTitle:金属有机框架纳米药物载体胞吞途径的研究进展
- Author:
Yu-xuan WANG
1
,
2
,
3
,
4
;
Wen-jia XIE
1
,
2
,
3
,
4
;
Hui-le GAO
5
;
Xi-bo PEI
1
,
2
,
3
,
4
Author Information
1. State Key Laboratory of Oral Diseases &
2. National Center for Stomatology &
3. National Clinical Research Center for Oral Diseases &
4. Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
5. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
- Publication Type:Research Article
- Keywords:
metal-organic framework;
rug carrier;
endocytosis;
nanomaterial;
rug therapy
- From:
Acta Pharmaceutica Sinica
2024;59(5):1196-1209
- CountryChina
- Language:Chinese
-
Abstract:
Metal-organic frameworks (MOFs) are crystalline materials with a multidimensional porous network structure, formed through coordination bonds with metal ions as nodes and organic ligands as connecting bridges. Due to their excellent physicochemical properties, MOFs have extensive applications in the field of biomedicine, ranging from antibacterials, drug carriers, imaging to sensors. Nanoscale metal-organic frameworks (nMOFs), commonly utilized drug carriers, can gain enhanced safety, targeted delivery, and superior therapeutic effect through endocytosis. In this review, we comprehensively summarize the factors influencing the endocytosis of nMOFs, focusing on three key physicochemical properties, particle size, morphology and surface modification. Based on different illness models, the review succinctly summarizes the latest advancements in understanding the endocytosis pathways of nMOFs while critically reflecting on the inherent limitations of current research methods. Lastly, the review offers valuable insights into future research methodologies and objectives, aiming to lay the groundwork and provide meaningful guidance for the synthesis and development of nMOFs as promising versatile drug carriers.
