Preparation of traditional Chinese medicine metal complexes supramolecular hydrogel and its multiple biological activity evaluation
10.16438/j.0513-4870.2023-1333
- VernacularTitle:中药金属配合物超分子水凝胶的制备及其多重生物活性评价
- Author:
Lin-ying WU
;
Wen-min PI
;
Xiao-yu LIN
;
Yao-zhi ZHANG
;
Ji-hui LU
;
Xue-mei HUANG
;
Peng-long WANG
- Publication Type:Research Article
- Keywords:
active ingredient of traditional Chinese medicine;
metal complex;
supramolecule;
hydrogel
- From:
Acta Pharmaceutica Sinica
2024;59(5):1306-1312
- CountryChina
- Language:Chinese
-
Abstract:
The effect of different concentrations of glycyrrhizic acid (GA) and Zn2+ on the self-assembly of metal complexes was investigated by forming metal complexes, and the properties and assembly mechanisms of the formed carrier-free supramolecular hydrogel were characterised. Scanning electron microscopy (SEM) and zeta potential were used to characterise the microscopic morphology and stability of the GA-Zn complex hydrogel, which had spherical-like particles of about 1 μm with good stability; the rheometer was used to detect its materialistic properties, which showed excellent stability, self-healing property and reversibility; through in vitro bacterial inhibition, it was found that the GA-Zn carrier-free supramolecular hydrogel has enhanced bacterial inhibition function after assembly. The hydrogel was also found to possess both anti-inflammatory and antioxidant efficacy when evaluated using LPS and H2O2 induced RAW 264.7 cell damage models, respectively. The above results suggest that GA-Zn hydrogel not only has good materialistic properties, but also possesses good antibacterial, anti-inflammatory and antioxidant activities, which has the value of clinical research as a carrier-free multi-functional antimicrobial dressing, and the present study provides a reference for the discovery of novel biomedical materials from active molecules of natural traditional Chinese medicine.
