Mechanisms of Acinetobacter baumannii iron acquisition and antimicrobial strategies based on the inhibition of iron uptake
10.16438/j.0513-4870.2023-1166
- VernacularTitle:鲍曼不动杆菌铁离子摄取机制与基于抑制铁摄取的抗菌策略
- Author:
Zhi-meng ZHANG
;
Xue-fu YOU
;
Jing PANG
- Publication Type:Research Article
- Keywords:
host iron starvation;
acquisition of iron;
italic>Acinetobacter baumannii;
bacterial resistance;
antimicrobial strategy
- From:
Acta Pharmaceutica Sinica
2024;59(5):1113-1125
- CountryChina
- Language:Chinese
-
Abstract:
Bacterial resistance has always been a challenge in the field of antibacterials research. As one of the most problematic pathogens causing nosocomial infections, Acinetobacter baumannii (A. baumannii) was a severe threaten to public health. In recent years, as the rate of multidrug-resistant, extensively drug-resistant, and even pan drug-resistant A. baumannii has been increasing, there is an urgent need to develop new strategies to combat this pathogen. Iron is an essential element for the survival and the infection process of A. baumannii. Bacteria have developed a series of iron uptake strategies to survive in conditions of the host iron starvation, including the secretion of siderophore for iron chelation, the uptake of ferroheme, and the transport of ferrous by Feo system. Developing antibacterial strategies to inhibit the iron uptake is an effective way to deal with A. baumannii infection. This article will review the mechanisms of iron uptake by A. baumannii and the antimicrobial strategies developed based on them.
