Research progress in regulation and mechanism of transcription factors on tanshinones
10.16438/j.0513-4870.2023-1110
- VernacularTitle:转录因子对丹参酮类物质调控作用及机制研究进展
- Author:
Yan-hong BAI
1
;
Lin-lin XIN
1
;
Ting ZENG
1
,
2
;
Feng-xia HAN
1
;
Yong-qing ZHANG
1
;
Gao-bin PU
1
;
Xue CHEN
1
;
Qian LIU
1
,
2
Author Information
1. College of Pharmacy, Shandong University of Chinese Medicine, Jinan 250355, China
2. LiShizhen College of Traditional Chinese Medicine, Huanggang Normal University, Huanggang 438000, China
- Publication Type:Research Article
- Keywords:
transcription factor;
tanshinone;
regulation;
molecular mechanism
- From:
Acta Pharmaceutica Sinica
2024;59(5):1218-1228
- CountryChina
- Language:Chinese
-
Abstract:
italic>Salvia miltiorrhiza, a commonly used traditional Chinese medicine, has been widely recognized for its blood-activating and stasis-removing properties in the clinical treatment of cardiovascular and cerebrovascular diseases. The synthesis and regulatory mechanism of tanshinones, the key active constituents of Salvia miltiorrhiza, have been a hot topic of research. The paper summarized the research findings on the regulation of tanshinone biosynthesis by transcription factors such as AP2/ERF, bHLH, MYB, bZIP, and WRKY in recent years. The review identifies the existing issues in the transcriptional regulation studies of Salvia miltiorrhiza and discusses the research direction of transcription factors in the regulation of tanshinone biosynthesis, providing a theoretical basis for the further discovery and utilization of functional genes involved in the regulation of tanshinone bioactive constituents.
