Mitochondrial Dysfunction and Huntington's Disease
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20241021.008
- VernacularTitle:线粒体功能障碍与亨廷顿病
- Author:
Jiangyu ZHAO
1
;
Xing GUO
Author Information
1. 南京医科大学基础医学院,江苏南京 211166
- Keywords:
mitochondrial dysfunction;
Huntington ' s disease;
mitochondrial dynamics;
mitochondrial energy metabolism;
mitochondrial calcium homeostasis
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2024;45(6):941-952
- CountryChina
- Language:Chinese
-
Abstract:
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by abnormal amplification of the CAG repeat of the huntingtin (HTT) gene. Its main clinical manifestations are movement disorders,cognitive decline,and psychiatric symptoms. The occurrence and development of HD is related to a variety of factors,and with the deepening of basic research,the relationship between mitochondrial dysfunction,including decreased energy production,abnormal mitochondrial dynamics,and calcium homeostasis. Huntington's disease has attracted more and more attention from researchers. In this review,we discuss the links that exist between the many forms of mitochondrial dysfunction and HD,with the aim of highlighting the important role of mitochondrial dysfunction in the development and progression of HD disease.
