Predictive Value of Inflammatory Markers to Differentiate Endometrial Lesions
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2024.0608
- VernacularTitle:炎症标志物在区分子宫内膜病变中的预测价值
- Author:
Yingxiang WANG
1
;
Jian GU
;
Jia WANG
Author Information
1. 中山大学附属第三医院妇科,广东广州 510630
- Keywords:
endometrial atypical hyperplasia;
endometrial cancer;
serum inflammatory markers;
tumor markers;
receiver operating characteristic curve
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2024;45(6):923-929
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To explore the predictive value of preoperative serum inflammatory indicators in endometrial cancer.[Methods]The laboratory and clinical pathological data of patients with endometrial atypical hyperplasia and endometrial cancer diagnosed by pathology from January 2020 to December 2023 in the Third Affiliated Hospital of Sun Yat-sen University were retrospectively analyzed. The differences in basic information between the two groups of patients were analyzed. The Mann-Whitney U test was used to compare the differences in preoperative serum inflammatory indicators and tumor markers between the two groups of patients. The ROC curve was used to analyze the specificity,sensitivity and optimal cutoff value of the different indicators. A total of 408 patients were included in the study,including 82 patients in the endometrial atypical hyperplasia group and 326 patients in the endometrial cancer group.[Results]There were statistical differences in preoperative serum leukocyte count (P=0.039),monocyte count (P=0.046),platelet count (P=0.0317),platelet/lymphocyte ratio (PLR) (P=0.017),CA-125 (P<0.0001),and HE4 (P<0.0001) between endometrial atypical hyperplasia and endometrial carcinoma. ROC curves were drawn for these different indicators,and the results showed that leukocyte (P=0.041),platelet (P=0.045),PLR (P=0.007),CA-125 (P<0.0001),and HE4 (P<0.0001) had statistically significant predictive values in endometrial carcinoma. Compared with single indicators,the combined indicator CA-125+HE4+PLR+leukocytes+monocytes had the largest AUC[0.76 (0.70-0.81)],and its predictive value is higher.[Conclusion]CA-125+HE4+PLR+leukocytes+monocytes combined screening can help to identify endometrial cancer,and provide effective information for patients with endometrial atypical hyperplasia and early endometrial cancer who are conservatively treated.
