Research Progress in N-cadherin Function
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20241030.002
- VernacularTitle:N-钙黏蛋白功能研究进展
- Author:
Wencan CHEN
1
;
Ti ZHOU
Author Information
1. 中山大学中山医学院生物化学与分子生物学系,广东广州510080
- Keywords:
N-cadherin;
regulation and function;
cell signal transduction;
pathogenesis;
clinical application
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2024;45(6):866-875
- CountryChina
- Language:Chinese
-
Abstract:
N-cadherin,also known as Neural-cadherin/Cadherin-2,is a calcium-dependent transmembrane glycoprotein that plays a crucial role in cell-to-cell adhesion,cell sorting,nerve development and a variety of physiological and pathological processes. In recent years,with the rapid development of molecular biology and cell biology,the functional research of N-cadherin has made remarkable progress,providing essential clues for understanding tumor metastasis and neurodegenerative diseases. In this paper,the main progress in N-cadherin functional research in recent years is reviewed,including its molecular structure,biological function,signal transduction mechanism and its role in diseases. Finally,the clinical application prospect and future research direction of N-cadherin are summarized. It is expected to provide some theoretical reference for future research and clinical application of N-cadherin as a new target for the treatment of diseases.
