Investigation of the relationship between metformin and sarcopenia-related traits based on Mendelian randomization
- VernacularTitle:基于孟德尔随机化探讨二甲双胍与肌少症相关特征的关联
- Author:
Yue ZHU
1
;
Yinghui JU
1
;
Yuying YANG
1
;
Menglin WANG
1
;
Rui WU
1
Author Information
1. Ion Medical Center of the First Affiliated Hospital of University of Science and Technology of China （Hefei Ion Medical Center），Hefei 230088，China
- Publication Type:Journal Article
- Keywords:
Mendelian randomization;
metformin;
sarcopenia;
low grip strength;
muscle mass;
relationship analysis
- From:
China Pharmacy
2024;35(22):2793-2798
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the relationship between metformin and sarcopenia-related traits. METHODS Based on the data from publicly genome-wide association study-related databases， using single nucleotide polymorphisms strongly associated with metformin as instrumental variables， the two-sample Mendelian randomization （MR） analysis methods [inverse variance weighting （IVW） method， MR-Egger regression method and weighted median estimator method] were employed to investigate the relationship between metformin and three sarcopenia-related traits （low grip strength， muscle mass and walking speed）. Cochran’s Q test was used to assess heterogeneity， MR-Egger intercept test was used to detect horizontal pleiotropy， and leave-one-out analysis was performed for sensitivity analysis. RESULTS The results of IVW method showed that metformin use was significantly associated with an increased risk of low grip strength （β＝1.550， 95%CI was 0.389-2.711， P＝0.009） and reduced limb muscle mass （right leg lean body mass： β＝－0.665， 95%CI was －1.018-－0.312， P＜0.001； left leg lean body mass： β＝－0.710， 95%CI was －1.049-－0.371，P＜0.001； right arm lean body mass： β＝－0.471， 95%CI was －0.890-－0.053， P＝0.027； left arm lean body mass： β＝－0.463， 95%CI was －0.865-－0.061， P＝0.024），but was not associated with walking speed. The results or causal effects of the other two methods are consistent with it. The Cochran’s Q test indicated some degree of heterogeneity in the result of this study. No horizontal pleiotropy was detected by the MR-Egger intercept test. The sensitivity analysis suggested that the results of this study were stable. CONCLUSIONS Metformin may increase the risk of sarcopenia.
