Determination of chloride，sulfate and bicarbonate ions in Compound polyethylene glycol electrolyte powder （Ⅲ） by ion chromatography
- VernacularTitle:离子色谱法测定复方聚乙二醇电解质散（Ⅲ）中氯离子、硫酸根和碳酸氢根的含量
- Author:
Xianhua ZHANG
1
;
Yuxin ZHAO
2
;
Haiyan ZHOU
1
;
Xiaolu ZHU
2
;
Dengyan LAI
1
;
Jiao ZHU
1
;
Tao PENG
1
;
Shichun YE
1
Author Information
1. Chongqing Jewelland Pharmaceutical Co.，Ltd.，Chongqing 401121，China
2. Chongqing Institute for Food and Drug Control/The Key Laboratory of Quality Testing for Narcotic and Psychotropic Drugs of the National Medical Products Administration，Chongqing 401121，China
- Publication Type:Journal Article
- Keywords:
ion chromatography;
Polyethylene glycol electrolyte powder （Ⅲ）;
chloride ion;
sulfate ion;
bicarbonate ion
- From:
China Pharmacy
2024;35(22):2769-2772
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To establish an ion chromatography method for the simultaneous determination of chloride， sulfate and bicarbonate ions in Polyethylene glycol electrolyte powder （Ⅲ）. METHODS The chromatographic column was a Dionex IonpacTM AS11-HC anion analysis column， with a Dionex IonPacTM AG11-HC guard column. The mobile phase was 10 mmol/L potassium hydroxide at an isocratic elution flow rate of 1.2 mL/min. The detector was a conductivity detector， and the suppressor was a Dionex AERS with a suppressor current of 30 mA. The column temperature was maintained at 30 ° C， and the injection volume was 10 μL. Chloride and sulfate contents were calculated by external standard method， while bicarbonate content was determined by double logarithmic fitting standard curve method. RESULTS Under these chromatographic conditions， chloride， sulfate and bicarbonate ions were effectively separated with linear ranges of 0.055 to 0.219 mg/mL （r＝0.999 9）， 0.155 to 0.618 mg/mL （r＝1.000 0）， and 0.065 to 0.121 mg/mL （r＝0.999 9）， respectively. The recoveries were 98.06% to 101.34%， 97.37% to 101.25%， and 97.16% to 99.81%， respectively， with RSDs of 1.1%， 1.3% and 1.0% （n＝9）. The RSDs for the evaluation of precision， accuracy， stability and ruggedness were all less than 2%. CONCLUSIONS The established ion chromatography is simple， rapid， accurate， precise and durable， can simultaneously determine the contents of chloride， sulfate and bicarbonate ions in Polyethylene glycol electrolyte powder （Ⅲ）， which is suitable for its quality control.
