Optimization of the freeze-drying process for sheep placenta slices
- VernacularTitle:羊胎盘冻干饮片炮制工艺的优化
- Author:
Yuqing FAN
1
,
2
;
Jing ZHU
2
;
Qi CHEN
1
;
Jinrong FU
3
;
Jinhong FU
3
Author Information
1. School of Pharmacy，Jiangxi University of Chinese Medicine，Nanchang 330004，China
2. Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine，Jiangxi University of Chinese Medicine，Nanchang 330004，China
3. Jiangxi Tianyuan Pharmaceutical Co.，Ltd.，Jiangxi Yichun 331208，China
- Publication Type:Journal Article
- Keywords:
sheep placenta;
AHP;
CRITIC;
orthogonal design;
TOPSIS;
freeze-drying;
process optimization
- From:
China Pharmacy
2024;35(22):2739-2743
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To optimize the freeze-drying process for sheep placenta slices. METHODS An orthogonal test design was used with pre-freezing time， drying time and drying temperature as indicators to screen for the optimal freeze-drying process for sheep placenta slices. The peptide content， ethanol-soluble extract content， and freeze-drying rate of sheep placenta were used as indicators，the analytic hierarchy process-criteria importance through intercriteria correlation （AHP-CRITIC） method was employed to determine the weight of each indicator and calculate the comprehensive score， which was verified using the technique for order of preference by similarity to ideal solution （TOPSIS） model. RESULTS The optimal preparation process was found to be the pre-freezing time of 2 hours， the drying time of 16 hours， and the drying temperature of 30 °C. The average values of peptide content， ethanol-soluble extract content， and freeze-drying rate for three batches of samples were 5.883 mg/mL， 27.1%， and 95.77%， respectively； the comprehensive scores of three batches were 96.42， 99.18 and 99.58， with RSD of 1.75%. CONCLUSIONS This study successfully optimized the freeze-drying process for sheep placenta slices， which can provide a reference for the quality standard setting and industrial production of this type of slice.
