Research progress in the mechanisms of radiation-induced skin injury
10.13491/j.issn.1004-714X.2024.05.020
- VernacularTitle:放射性皮肤损伤相关机制及其研究现状
- Author:
Yuhua TIAN
1
;
Wenfeng GOU
2
;
Feifei XU
2
;
Yiliang LI
2
;
Wenbin HOU
2
Author Information
1. Tianjin University of Traditional Chinese Medicine, Tianjin 301617 China.
2. Peking Union Medical College & Institute of Radiological Medicine, Chinese Academy of Medical Sciences, Tianjin 300192 China.
- Publication Type:ReviewArticles
- Keywords:
Radiation-induced skin injury;
Oxidative stress;
DNA damage;
Inflammation;
Vascular damage;
Fibrosis;
Targeted drug
- From:
Chinese Journal of Radiological Health
2024;33(5):607-614
- CountryChina
- Language:Chinese
-
Abstract:
With the rapid development of radiotherapy technology, the therapeutic outcomes of tumor patients have improved significantly, enabling effective disease control. However, during radiotherapy, the skin as the first barrier of the human body is inevitably exposed to radiation, leading to superficial skin injury. This injury often manifests as blistering, cracking, bleeding, and ulceration, resulting in wounds that are difficult to heal and potentially affecting the effectiveness of the treatment. At present, the therapeutic effect of drugs on radiation-induced skin injury remains limited, and the development of new drugs depends on the elucidation of the mechanisms. Therefore, it is crucial to investigate the mechanisms of radiation-induced skin injury. This article reviews these mechanisms, including DNA damage, oxidative stress, inflammatory response, and vascular damage and fibrosis, and summarizes the therapeutic drugs and targeted proteins in recent years, aiming to provide a reference for the further development and clinical application of drugs for radiation-induced skin injury.
