Impact of 177Lu-DOTATATE therapy on radiation exposure of ward healthcare staff and accompanying persons
10.13491/j.issn.1004-714X.2024.05.004
- VernacularTitle:177Lu-DOTATATE治疗对病房内工作人员及公众的辐射影响
- Author:
Xuesong SU
1
;
Jinming ZHANG
2
;
Jianhua GENG
1
;
Yingmao CHEN
2
;
Gaofeng LI
3
;
Xuejuan WANG
1
Author Information
1. Department of Nuclear Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021 China.
2. Department of Nuclear Medicine, First Medical Center of Chinese PLA General Hospital, Beijing 100853 China.
3. Beijing Explore Times Technology Co. Ltd, Beijing 102600 China.
- Publication Type:OriginalArticles
- Keywords:
177Lu -DOTATATE;
Therapy;
Radioactive aerosol;
Surface contamination;
Ambient dose equivalent rate
- From:
Chinese Journal of Radiological Health
2024;33(5):510-516
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate air radioactivity contamination, surface contamination, ambient dose equivalent rates, and radiation doses to individuals in the treatment room during 177Lu-DOTATATE therapy. Methods A ward for 177Lu-DOTATATE therapy was selected in the nuclear medicine department of a general hospital. Air and surface radioactivity samples were collected before and after therapy for four patients. Ambient dose equivalent rates were measured around the four patients following the initiation of 177Lu-DOTATATE therapy. Measurements were taken at distances of 0.1, 0.3, 0.5, and 1−4 m (with 0.5 m intervals) from the right lateral midsection of the patient’s torso. The measurement time points included 5, 15, and 30 min after initiation of administration, as well as 0−4 h (with 1 h intervals), 24 h, and 48 h post-administration. Radiation exposure doses for personnel at different distances from the patients were calculated for each time interval. Results The results of radioactive aerosol detection for all four patients during and after the administration of 177Lu-DOTATATE were similar to those before administration. Surface contamination was not detected at the measurement locations except for patient number 2. The ambient dose equivalent rates increased with increasing injection dose during the administration. However, the ambient dose equivalent rates decreased significantly within one hour after administration. At the end of the administration, the average ambient dose equivalent rate at a distance of one meter for the four patients was 42.931 μSv/h. From the start of administration to four hours post-administration, personnel maintaining a distance of one meter from the patient received a total radiation dose of 167.64 μSv. Conclusion Air radioactivity contamination does not occur during 177Lu-DOTATATE therapy. However, measures should be taken before the commencement of therapy to address potential surface contamination. Both accompanying persons and healthcare staff receive radiation doses below the stipulated dose constraints throughout the treatment process. Therefore, it is necessary to implement appropriate measures to minimize the radiation exposure of healthcare staff.
