Clinical Observation on 40 Cases of Benign Thyroid Nodules with Qi Constraint and Phlegm Obstruction Syndrome by External Application of Sanjie Waifu Formula （散结外敷方）
10.13288/j.11-2166/r.2024.21.011
- VernacularTitle:散结外敷方贴敷治疗气郁痰阻型良性甲状腺结节40例临床观察
- Author:
Jinmei ZHANG
1
;
Lian LYU
2
;
Xinqi LIU
1
;
Qiaoyi WANG
1
;
Aiqiu WANG
1
;
Liqin WANG
1
Author Information
1. Weifang Traditional Chinese Hospital，Weifang，Shandong Province，261041
2. Shandong University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
benign thyroid nodules;
Sanjie Waifu Formula （散结外敷方）;
qi constraint and phlegm obstruction;
effectiveness of traditional Chinese medicine syndrome;
thyroid function;
external application of Chinese herbal medicine
- From:
Journal of Traditional Chinese Medicine
2024;65(21):2234-2239
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the clinical effectiveness and safety of Sanjie Waifu Formula （散结外敷方） application therapy for benign thyroid nodules of qi constraint and phlegm obstruction syndrome. MethodsEighty patients with benign thyroid nodules of qi constraint and phlegm obstruction syndrome were randomly divided into 40 cases each in a treatment group and a control group. The control group was given health education and follow-up observation， while the treatment group applied Sanjie Waifu Formula externally on the basis of the control group，6~8 h each time ， once a day. Both groups took 30 days as a course， and were observed for 3 consecutive courses. The main effectiveness indexes of both groups were compared before and after treatment， including the volume of thyroid nodules， the maximum diameter of the largest nodule， the scores of traditional Chinese medicine （TCM） syndrome， and the secondary effectiveness indexes of serum thyroid function including free triiodothyronine （FT3）， free thyroxine （FT4）， thyrotropin （TSH） levels were also observed. The effectiveness of the TCM syndrome of both groups was compared after treatment. Meanwhile， the safety indexes were observed before and after treatment， such as the blood routine， liver and kidney function indexes， and the occurrence of adverse reactions during the study was recorded. ResultsCompared with in group before treatment， the volume of thyroid nodules， the maximum diameter of the largest nodule， and the TCM symptom scores were lowered in both groups after treatment （P＜0.05 or P＜0.01）. Comparing between groups after treatment， the difference in thyroid nodule volume was not statistically significant （P＞0.05）， but the maximum diameter of the largest nodule and the TCM symptom scores of the treatment group were lower than those of the control group （P＜0.01）. The total effective rate of TCM syndrome in the treatment group was 77.50% （31/40）， which was significantly higher than that of the control group with 52.5% （21/40， P＜0.01）. Thyroid function， blood routine and liver and kidney function indexes of both groups before and after treatment were compared between and within groups， and the differences were not statistically significant （P＞0.05）， and they were all within the normal range. During the treatment period， no allergic reactions such as skin itching， red rash and blisters occurred in the treatment group. ConclusionThe external application of Sanjie Waifu Formula can improve the clinical symptoms of patients with benign thyroid nodules， reduce volume and the maximum diameter of nodules， and has no significant effects on thyroid function and show good safety.
