Mechanism of Bone Destruction in Rheumatoid Arthritis Based on the Theory of Kidney Deficiency and Essence Deficiency
10.13288/j.11-2166/r.2024.19.015
- VernacularTitle:基于肾虚精亏理论探讨类风湿关节炎骨破坏的发生发展机制
- Author:
Wenju ZHU
1
;
Xiaojun SU
2
;
Qian HE
1
;
Huan WANG
1
;
Zhiming ZHANG
2
;
Haili SHEN
3
;
Xiaotao YE
1
Author Information
1. Gansu University of Chinese Medicine，Lanzhou，730030
2. Gansu Provincial Hospital of Traditional Chinese Medicine
3. Lanzhou University No.2 Hospital
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
bone destruction;
kidney deficiency and essence deficiency;
bones withering and marrow reducing;
imbalance of muscles and bones;
phlegm-dampness stasis obstruction
- From:
Journal of Traditional Chinese Medicine
2024;65(19):2045-2049
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis is a common clinical autoimmune disease characterized by persistent synovitis and pannus formation. In late stage， irreversible destruction and deformation of bone and joint may occur. In this paper， the authors believe that kidney deficiency and essence deficiency is the core mechanism of rheumatoid arthritis bone destruction， and its disease evolution law is summarized as "marrow reduction， flesh flaccid， collaterals blocked". On the basis of modern medical understanding of bone destruction in rheumatoid arthritis， it is considered that the mechanism in Chinese medicine of "marrow reduction， flesh flaccid， collaterals blocked" ultimately leads to bone destruction， is similar to that in the western medicine of abnormal differentiation of osteoclasts， high expression of nuclear factor-κB receptor activator of ligand， and abnormal expression of inflammatory factors. This point of view may provide a more comprehensive and scientific understanding of the key pathogenic mechanism of bone destruction in rheumatoid arthritis.
