Discussing the Staged Treatment of Progressive Fibrosing Interstitial Lung Disease Based on the Theory of

Haoxiang Zhang; Jin'e Wang; Xiao Xia; Yanyi Liu; Yujin Ding; Yingzi Tian; Kun Xia; Guangxi LI

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Discussing the Staged Treatment of Progressive Fibrosing Interstitial Lung Disease Based on the Theory of "Opening-Closing-Pivoting"

VernacularTitle:基于开阖枢理论分期论治进行性纤维化间质性肺病
Author: Haoxiang ZHANG ¹ ; Jin'e WANG ¹ ; Xiao XIA ¹ ; Yanyi LIU ¹ ; Yujin DING ¹ ; Yingzi TIAN ¹ ; Kun XIA ¹ ; Guangxi LI ¹
Author Information

1. Guang'anmen Hospital，China Academy of Chinese Medical Sciences，Beijing，100053
Publication Type:Journal Article
Keywords: progressive fibrosing interstitial lung disease; opening-closing-pivoting; lung impediment; lung atrophy
From: Journal of Traditional Chinese Medicine 2024;65(18):1882-1887
CountryChina
Language:Chinese
Abstract: Progressive fibrosing interstitial lung disease （PF-ILD） has a complex etiology， and is classified as lung impediment stage， impediment-atrophy combination stage， and lung atrophy stage according to the different clinical manifestations during the progression of disease. Based on the theory of opening-closing-pivoting to analyse the characteristics of yin and yang disease mechanism and the idea of prescriptions in the three stages. For lung impediment stage， main as three-Yang fail to keep inside， disharmony between Ying qi （营气） and Wei qi （卫气）， shaoyin impairment， treatment should use Mahuang （Ephedra sinica） and Guizhi （Neolitsea cassia） flexibly to form a formula， or choose pungent-dispersing formulas like Baidu Powder （败毒散） to move qi and save yang， and diffuse and disperse impediment pathogen， meanwhile combining saving-shaoyin medicinals like Fuzi （Aconitum carmichaelii） and Shudihuang （Radix Rehmanniae Praeparata） to reinforce healthy qi and dispel pathogen； for impediment-atrophy combination stage， rooted as yangming impairment and progressed by over-movement of qi， treatment should use Mahuang Shengma Decoction （麻黄升麻汤） to resolve and decrease over-activities， emphasis on both opening and closing， and improve impediment and atrophy； for lung atrophy stage with three-Yin in a bad condition simultaneously and poor prognosis， treatment should use modified Jinshui Liujun Decoction （金水六君煎） to consolidate qi and save yin， disperse phlegm and stasis， to improve the quality of life for patients with PF-ILD.