Interactions between gut microbiota-producing enzymes and natural drugs affect disease progression
10.16438/j.0513-4870.2024-0363
- VernacularTitle:肠道菌产生酶与天然药物互作对疾病的影响
- Author:
Zhi-yu WANG
1
;
Hao-ran SHEN
1
;
Yan-xing HAN
1
;
Jian-dong JIANG
1
,
2
;
Wei JIANG
3
;
Hui-hui GUO
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
3. Zhejiang Zhenyuan Pharmaceutical Co., Ltd., Shaoxing 312000, China
- Publication Type:Research Article
- Keywords:
natural medicine;
gut microbiota;
gut microbiota-producing enzyme;
isease progression;
rug research and development
- From:
Acta Pharmaceutica Sinica
2024;59(8):2183-2191
- CountryChina
- Language:Chinese
-
Abstract:
Naturally derived metabolites are valuable resources for drug research and development, and play an important role in the treatment of diseases. As the "second genome" of the body, gut microbiota is rich in metabolic enzymes, which interacts with external substances such as drugs, thus affecting the progression of diseases. This article summarizes the interaction between gut microbiota-producing enzymes and natural medicines, and focuses on the impact of this interaction on disease progression, hoping to provide new ideas for the development and pharmacological mechanism of natural medicines.
