A new cadinane-type sesquiterpenoid and a new natural product from the aerial parts of Pogostemon cablin
10.16438/j.0513-4870.2024-0004
- VernacularTitle:广藿香中一个新的杜松烷型倍半萜和一个新天然产物
- Author:
Yu-mei FENG
;
Jian-xian TANG
;
Zhi-yuan LIU
;
Rong-tao LI
;
Hong-mei LI
- Publication Type:Research Article
- Keywords:
italic>Pogostemon cablin;
Lamiaceae;
chemical constituent;
cadinane-type sesquiterpenoid;
new natural product
- From:
Acta Pharmaceutica Sinica
2024;59(8):2295-2299
- CountryChina
- Language:Chinese
-
Abstract:
A new cadinane-type sesquiterpenoid, pogocablene P (1), and a new natural product with cyclohexanone skeleton, pogocablone A (2), were isolated from the EtOAc soluble fraction of the aerial parts of Pogostemon cablin by several chromatographic methods, such as silica gel, Sephadex LH-20, ODS and high performance liquid chromatography (HPLC), and so on. Their structures were identified by means of mass spectrometry and nuclear magnetic resonance spectroscopy. In addition, the absolute configuration of compound 2 was determined by electronic circular dichroism (ECD) calculation. Furthermore, the anti-influenza virus and anti-inflammatory activities of compounds 1 and 2 were evaluated.
