Advances in gastric retention drug delivery system

VernacularTitle:胃滞留给药系统的研究进展
Author: Yan-mei WU ; Feng-xue LIU ; Ping GONG ; Ning CHEN ; Wei ZHENG
Publication Type:Research Article
Keywords: gastric retention drug delivery system; retention time; bioavailability; compliance; italic>in vivo and in vitro evaluation
From: Acta Pharmaceutica Sinica 2024;59(9):2499-2508
CountryChina
Language:Chinese
Abstract: The conventional oral drug delivery frequently results in the drug elimination before its complete release due to rapid gastric emptying and short gastrointestinal transport time, thus reducing the bioavailability of drug. In order to maintain an effective concentration of drug in the body and maximize its optimal efficacy, the frequency of administrations often needs to be increased. By contrast, gastric retention drug delivery system (GRDDS), as an innovative method of drug delivery, prolongs the retention time of the drug in the stomach and reduces irritation to the gastrointestinal tract. Consequently, it enhances the bioavailability of drug, reduces dosing frequency for patients and improves treatment adherence. In recent years, domestic and foreign studies have been conducted on gastric retention drug delivery systems. Here, we provide a comprehensive overview of the relevant literature published in recent years, examining their current marketing status, various types, as well as in vivo and in vitro evaluation methods.