Research progress of nanomedical drug delivery system based on aerobic glycolytic regulation for tumor therapy
10.16438/j.0513-4870.2024-0068
- VernacularTitle:基于有氧糖酵解调节的纳米药物递送系统用于肿瘤治疗的研究进展
- Author:
Yi-jing LI
1
;
Sheng-nan HUANG
2
,
3
;
Zi-ang WANG
1
;
Wei-wei ZHI
1
;
Xia-li ZHU
1
Author Information
1. Pharmacy College, Henan University of Chinese Medicine, Zhengzhou 450046, China
2. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China
3. Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China
- Publication Type:Research Article
- Keywords:
aerobic glycolysis;
nano drug delivery system;
tumor therapy;
combined therapy
- From:
Acta Pharmaceutica Sinica
2024;59(9):2509-2518
- CountryChina
- Language:Chinese
-
Abstract:
Tumor is one of the serious problems threatening human health. There are some limitations in the delivery of commonly used tumor therapy technologies, and the therapeutic effect is not satisfactory, so new anti-tumor strategies need to be developed. The process of tumor cells using glycolysis to produce energy under aerobic conditions is called aerobic glycolysis, which is closely related to tumor growth, proliferation and metastasis, and can provide a new target spot for tumor treatment. Nano drug delivery system has been widely used in targeted tumor therapy because of its advantages of targeted drug delivery, improved anti-tumor efficacy and reduced toxic side effects. Numerous studies have shown that more and more nano drug delivery systems regulates aerobic glycolytic metabolism by targeting to potential targets such as signaling factors or reaction products of aerobic glycolytic process in tumors, and therefore enhance the anti-tumor effect. This paper reviews the application of nano drug delivery system in regulating tumor aerobic glycolysis, and provides theoretical references for realizing efficient targeted tumor therapy.
