Progress in delivering biotechnology drugs on microneedles
10.16438/j.0513-4870.2024-0530
- VernacularTitle:微针递送生物技术药物的研究进展
- Author:
Han LIU
1
;
Guo-zhong YANG
1
;
Wan-ren DU
1
;
Suo-hui ZHANG
1
,
2
;
Ze-quan ZHOU
1
;
Yun-hua GAO
1
,
2
Author Information
1. Zhongke Microneedle (Beijing) Technology Company Limited, Beijing 100000, China
2. Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100000, China
- Publication Type:Research Article
- Keywords:
microneedle;
transdermal delivery;
biotechnology drug;
classification;
stability
- From:
Acta Pharmaceutica Sinica
2024;59(10):2751-2762
- CountryChina
- Language:Chinese
-
Abstract:
As a new transdermal drug delivery system, microneedles can significantly improve skin permeability, enhance drug transdermal delivery, and demonstrate unique advantages in breaking stratum corneum barrier of skin. This feature enables microneedles to demonstrate enormous potential in delivering biotechnology drugs. The traditional delivery method for biotechnology drugs is mainly injection, which brings problems such as pain and skin redness to patients, leading to poor patient compliance. In addition, the production, transportation, and storage of biotechnology drugs require strict low-temperature conditions to maintain their activity and increase cost output. Microneedles, by contrast, have many benefits, providing new avenues and solutions for biomolecular delivery. Accordingly, this review introduced the microneedle drug delivery system for delivery biotechnology drugs, and summarized the research progress of microneedle systems in biotechnology drugs.
